Journal article
Prospective validation of the breast cancer risk prediction model BOADICEA and a batch-mode version BOADICEACentre
RJ MacInnis, A Bickerstaffe, C Apicella, GS Dite, JG Dowty, K Aujard, KA Phillips, P Weideman, A Lee, MB Terry, GG Giles, MC Southey, AC Antoniou, JL Hopper
British Journal of Cancer | Published : 2013
DOI: 10.1038/bjc.2013.382
Abstract
Background:Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) is a risk prediction algorithm that can be used to compute estimates of age-specific risk of breast cancer. It is uncertain whether BOADICEA performs adequately for populations outside the United Kingdom.Methods:Using a batch mode version of BOADICEA that we developed (BOADICEACentre), we calculated the cumulative 10-year invasive breast cancer risk for 4176 Australian women of European ancestry unaffected at baseline from 1601 case and control families in the Australian Breast Cancer Family Registry. Based on 115 incident breast cancers, we investigated calibration, discrimination (using ..
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Grants
Awarded by National Cancer Institute
Funding Acknowledgements
The ABCFR is the Australian site of the Breast Cancer Family Registry, and this work was supported by grant UM1 CA164920 from the National Cancer Institute. The content of the manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centres in the Breast Cancer Family Registry (BCFR), nor does mention of trade names, commercial products or organisations imply endorsement by the US Government or the BCFR. The Australian Breast Cancer Family Registry was also supported by the National Health and Medical Research Council (NHMRC) of Australia, the New South Wales Cancer Council and the Victorian Health Promotion Foundation. RJM is a NHMRC Sidney Sax Postdoctoral Research Fellow. K-AP is a National Breast Cancer Foundation Practitioner Fellow. ACA is a Cancer Research UK Senior Cancer Research Fellow (C12292/A11174). MCS is a NHMRC Senior Research Fellow and JLH is a NHMRC Senior Principal Research Fellow and was supported by the Distinguished Scholars Invitation Program at Seoul National University.